To filter out the vocals you need a Karaoke filtering program or a good eq to filter out the vocal range. It is really a bit of magic though as it depends on the song as to how well the vocals can be filtered out. Sometimes it helps too to run the left and right channels out of phase as this will cancel out the mono content more effectively and vocals are usually mono or l/r equally.

Actually, intelliScore will do the process described by ElvesBrew.  In the Project Editor, go to the Audio tab.  In the Stereo frame, select the Cancel radio button.  This will help remove sounds from the center of the stereo image.  Often, vocals are mixed to stereo center, so this can help remove the vocals.